Which of the following best describes asthma?

Question

BlackTom AI · Accepted Answer

Asthma is a chronic inflammatory disorder of the airways characterized by bronchial hyperresponsiveness that produces recurrent episodes of wheezing, breathlessness, chest tightness and coughing, especially at night or early morning. Inflammation (eosinophils, mast cells, Th2 cytokines, IgE in atopic asthma) plus reversible bronchial smooth muscle constriction, mucus hypersecretion and airway edema lead to episodic bronchospasm and variable airflow obstruction.

1. Relevant knowledge points and concepts
- Asthma: chronic airway inflammation + bronchial hyperresponsiveness → episodic, often reversible airway obstruction.
- Clinical features: wheeze, cough, dyspnea; improved with bronchodilators.
- Pathophysiology: inflammatory cells, bronchospasm, mucus plugging, possible airway remodeling with chronic disease.
- Distinction from other pulmonary conditions: pneumonia (alveolar infection), lymphatic malignancy (lymphoma), restrictive diseases (reduced lung volumes, e.g., pulmonary fibrosis).

2. Step-by-step reasoning
- Option a states “A chronic inflammatory disorder causing episodic bronchospasm with airway obstruction.” This matches core pathophysiology and clinical pattern of asthma: chronic inflammation → episodic bronchospasm and reversible obstruction.
- Evaluate other options to exclude them (see next section).

3. Calculations/intermediate steps
- No numeric calculations required; logical elimination based on definitions and pathology.

4. Why the correct answer is correct
- Asthma’s defining features are chronic airway inflammation and episodic bronchospasm producing airflow obstruction that is typically variable and reversible with treatment (bronchodilators, anti-inflammatory therapy). Option a precisely describes these elements.

5. Why the other options are incorrect
- b: “A bacterial infection that fills alveoli with pus” describes lobar or bronchopneumonia, not asthma.
- c: “A malignancy of the lymphatic system” defines lymphoma, unrelated to asthma’s airway inflammation.
- d: “A restrictive disease causing permanent loss of alveolar surface area” refers to conditions that reduce lung volumes or emphysematous destruction (emphysema is actually obstructive), not the episodic bronchospasm and reversible obstruction seen in asthma.

Conclusion: The best description is option a. This confirms the provided correct answer: a.

Which of the following best describes asthma?单项选择题

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