When nucleotides polymerize to form a nucleic acid, ________.

Question

BlackTom AI · Accepted Answer

When nucleotides polymerize to form a nucleic acid, the key chemical linkage that bakes the backbone is a covalent bond, specifically a phosphodiester bond, formed between the sugar of one nucleotide and the phosphate of the next. 
Option A states that hydrogen bonds form between the bases of two nucleotides; while hydrogen bonds do stabilize base pairing in double-stranded nucleic acids, they are not the bonds that link nucleotides together in the backbone during polymerization. They occur later between complementary bases across strands, not in the backbone linkage. 
Option B correctly identifies that a covalent bond forms between the sugar of one nucleotide and the phosphate of a second, which is the phosphodiester bond that chains nucleotides into a polymer. 
Option C says covalent bonds form between the bases of two nucleotides; bases are attached to the sugar, and the bases themselves do not form covalent links with each other during polymerization; instead, they pair via hydrogen bonding in the assembled structure, not by backbone linkage. 
Option D claims a hydrogen bond forms between the sugar and the phosphate of adjacent nucleotides; this is incorrect because hydrogen bonds are not the bond type that connects nucleotides to form the backbone. The actual connection is a covalent phosphodiester linkage between the sugar’s phosphate group and the adjacent nucleotide’s phosphate-sugar arrangement. 
Thus, the statement describing the formation of a covalent phosphodiester bond between the sugar of one nucleotide and the phosphate of the next correctly characterizes nucleic acid polymerization.

When nucleotides polymerize to form a nucleic acid, ________. 单项选择题

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