Deoxyribonucleic acid (DNA) is a double-stranded duplex of deoxyribonucleic acids (i.e. purine and pyrimidine bases) joined together by a backbone of alternating sugar and phosphate groups (see below).

What type of bond links the nucleic acids in the DNA backbone together?

Question

Deoxyribonucleic acid (DNA) is a double-stranded duplex of deoxyribonucleic acids (i.e. purine and pyrimidine bases) joined together by a backbone of alternating sugar and phosphate groups (see below).

What type of bond links the nucleic acids in the DNA backbone together?

BlackTom AI · Accepted Answer

To begin, the question asks about the type of bond that links nucleic acids in the DNA backbone.
The given answer option is 'Phosphodiester'. This bond type specifically connects the 5' phosphate group of one nucleotide to the 3' hydroxyl group of the adjacent nucleotide via a phosphate linker, forming the sugar-phosphate backbone characteristic of DNA and RNA. The result is a repeating sugar-phosphate chain with nucleotide bases extending inward toward the interior of the double helix.
In this case, since the backbone is described as the alternating sugar and phosphate groups, the linking bond must be a phosphate-ester linkage, which is precisely the phosphodiester bond when two nucleotides are connected. This preserves the directional polarity of the strand (5' to 3').
If we consider alternative bond types conceptually (though not listed here), a glycosidic bond would connect the base to the sugar, not link nucleotides along the backbone; a peptide bond would join amino acids in proteins; a hydrogen bond helps stabilize base pairing between strands but does not form the backbone linkage; and a phosphodiester bond, by definition, is the backbone-connecting linkage in nucleic acids.
Because the prompt’s provided answer is 'Phosphodiester' and aligns with the accepted chemistry of DNA structure, that choice correctly identifies the backbone linkage.
Note: The question did not present multiple answer choices to evaluate against, so this analysis focuses on validating why phosphodiester bonds are the correct backbone linkages in DNA and why other bond types would not fulfill that role.

Deoxyribonucleic acid (DNA) is a double-stranded duplex of deoxyribonucleic acids (i.e. purine and pyrimidine bases) joined together by a backbone of alternating sugar and phosphate groups (see below). What type of bond links the nucleic acids in the DNA backbone together? 单项选择题

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