Question17 What is the major activator of glycolysis in most cells? Select one alternative: NADH NAD+ FADH2 AMP ATP ResetMaximum marks: 1 Flag question undefined单项选择题
A
NADH
B
NAD+
C
FADH2
D
AMP
E
ATP

Question

Question17 What is the major activator of glycolysis in most cells? Select one alternative: NADH NAD+ FADH2 AMP ATP ResetMaximum marks: 1 Flag question undefined

BlackTom AI · Accepted Answer

Question17 What is the major activator of glycolysis in most cells? Select one alternative: NADH NAD+ FADH2 AMP ATP

Option 1: NADH — This molecule is primarily a product of glycolysis and the TCA cycle, and high NADH levels reflect a reduced cellular state. Rather than activating glycolysis, elevated NADH tends to signal enough energy and can contribute to feedback inhibition of glycolytic enzymes, making it an unlikely activator.

Option 2: NAD+ — NAD+ serves as an oxidizing agent in several dehydrogenase steps (e.g., glyceraldehyde-3-phosphate dehydrogenase), but it is not the principal trigger that accelerates glycolysis. The glycolytic flux is more tightly tied to energy status indicators than to simply the presence of NAD+.

Option 3: FADH2 — FADH2 is another reduced carrier that donates electrons to the electron transport chain. Its production reflects oxidative metabolism rather than serving as the direct activator of glycolysis, so it does not function as the major glycolytic activator.

Option 4: AMP — This is the key activator. AMP signals low cellular energy and allosterically stimulates phosphofructokinase-1 (PFK-1), the rate-limiting enzyme of glycolysis, thereby ramping up glycolytic flux to generate ATP. This matches the classic view that low energy state (high AMP) drives glycolysis forward.

Option 5: ATP — ATP indicates high energy charge and inhibits glycolysis through allosteric effects on PFK-1 and other enzymes, reducing the pathway’s throughput when energy is plentiful. Therefore, ATP is not an activator.

In summary, AMP stands out as the major activator of glycolysis by promoting PFK-1 activity and increasing glycolytic flux under low-energy conditions, while the other molecules either reflect energy status or act as inhibitors rather than activators.

Question17 What is the major activator of glycolysis in most cells? Select one alternative: NADH NAD+ FADH2 AMP ATP ResetMaximum marks: 1 Flag question undefined单项选择题

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