Question at position 12 The most common brain tumor, glioblastoma, is derived from:NeuronsOligodendrocytesAstrocytesMicrogliaClear my selection单项选择题
A
Neurons
B
Oligodendrocytes
C
Astrocytes
D
Microglia

Question

Question at position 12 The most common brain tumor, glioblastoma, is derived from:NeuronsOligodendrocytesAstrocytesMicrogliaClear my selection

BlackTom AI · Accepted Answer

Glioblastoma (GBM) is an astrocytic tumor: it is the WHO grade IV malignant form of astrocytoma and therefore derives from astrocytes.

1. Relevant knowledge points and concepts
- Central nervous system (CNS) cell types include neurons and glial cells (astrocytes, oligodendrocytes, microglia).  
- "Glioma" denotes tumors arising from glial cells; subtypes are named for the glial cell of origin (astrocytoma from astrocytes, oligodendroglioma from oligodendrocytes).  
- Glioblastoma multiforme (GBM) is the most common and most malignant primary brain tumor in adults (WHO grade IV). Key histologic features: pseudopalisading necrosis and microvascular proliferation. GBMs commonly express the intermediate filament GFAP, an astrocytic marker.

2. Step-by-step reasoning
- Step 1: Recognize the tumor name: "glioblastoma" implies a glial origin.  
- Step 2: Distinguish which glial cell type produces the common malignant glioma: the highest-grade astrocytic tumor is GBM.  
- Step 3: Use histopathology and marker data: GBMs are GFAP-positive, consistent with astrocytic differentiation, and display morphological features typical of astrocyte-derived malignancy.

3. Intermediate steps (elimination)
- Neurons: Primary neuronal tumors are rare; GBM is not neuronal in origin.  
- Oligodendrocytes: Oligodendrogliomas are distinct entities (with 1p/19q co-deletion and different histology), not GBM.  
- Microglia: These are immune cells (macrophage-lineage); primary tumors from microglia are not the typical glioblastomas.

4. Why the correct answer is correct
Astrocytes are the precursor cells for astrocytomas; glioblastoma is the most aggressive form of astrocytoma (WHO grade IV), exhibiting astrocytic markers (GFAP) and classic pathological features, confirming astrocytic origin.

5. Why other options are incorrect (brief)
- Neurons: neuronal tumors are distinct and much less common; GBM lacks neuronal differentiation.  
- Oligodendrocytes: produce oligodendrogliomas with different genetics/histology, not GBM.  
- Microglia: are immune cells, not the source of GBM.

6. Conclusion
Therefore, the correct answer is Astrocytes, matching the provided answer.

Question at position 12 The most common brain tumor, glioblastoma, is derived from:NeuronsOligodendrocytesAstrocytesMicrogliaClear my selection单项选择题

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