How does the enzyme CYP3A4 contribute to drug metabolism?[Fill in the blank]

Question

BlackTom AI · Accepted Answer

To start, let's examine what CYP3A4 does in drug metabolism. This enzyme is a member of the cytochrome P450 family and primarily mediates oxidative transformations.
Option a: By hydrolysing drugs into smaller molecules. Hydrolysis is typically carried out by other enzymes (like certain esterases or amidases), not the classic CYP450 monooxygenase reactions, so this is incorrect for CYP3A4.
Option b: By adding an oxygen atom to the drug molecule. This describes the core reaction of many CYP450 enzymes, including CYP3A4, which introduces an oxygen (oxidation) into substrates, often forming hydroxylated metabolites. This is correct.
Option c: By conjugating drugs with glucuronic acid. Glucuronidation is handled by UDP-glucuronosyltransferases (UGTs), not CYP3A4, so this is false for this enzyme.
Option d: By transporting drugs across cell membranes. Transport across membranes is a function of transporters (e.g., P-glycoprotein, various solute carriers), not the catalytic oxidation performed by CYP3A4, making this option incorrect.

How does the enzyme CYP3A4 contribute to drug metabolism?[Fill in the blank]单项选择题

类似问题

Cyclophosphamide must be activated by which organ before it can cause crosslinks between DNA strands?

Which of the following statements about metabolism is TRUE:[Fill in the blank]

Which of the following statements about metabolism is TRUE:

If a prodrug is converted into its bioactive form through metabolism by a cytochrome P450 enzyme then:

Which is primarily responsible for pharmacologic metabolism?

The liver has an important role in drug ADME. Which ONE of the following is CORRECT?

Where are lidocaine, mepivacaine, and bupivacaine metabolized?

更多留学生实用工具

智能学习助手

风格化写作助手

论文查重助手

文献引用助手

课堂转译助手

课堂笔记助手

Quiz搜索助手

学校历年真题

智能刷题助手

智能匹配练习

希望你的学习变得更简单