Question26 The ED50 ascribed to a drug quantifies the mid-point of the: Molecular weight Dose-response curve Blood-brain transportation Receptor density ResetMaximum marks: 1 Flag question undefined单项选择题
A
Molecular weight
B
Dose-response curve
C
Blood-brain transportation
D
Receptor density

Question

Question26 The ED50 ascribed to a drug quantifies the mid-point of the: Molecular weight Dose-response curve Blood-brain transportation Receptor density ResetMaximum marks: 1 Flag question undefined

BlackTom AI · Accepted Answer

ED50 denotes the dose producing 50% of a drug’s maximal effect, so it directly refers to the midpoint of a dose–response curve.

1. Relevant knowledge points and concepts
- ED50 (median effective dose) = the dose at which 50% of the maximal pharmacologic effect is observed (or 50% of subjects show a defined response).
- Dose–response curve: a plot of drug dose (x-axis) versus effect or response (y-axis), typically sigmoid for many drugs.
- Other related terms: EC50 (concentration producing 50% of maximal effect), LD50 (lethal dose for 50% of subjects), and concepts like receptor density or blood–brain barrier that influence but are not defined by ED50.

2. Step-by-step reasoning
- A dose–response curve describes how effect changes with increasing dose.
- The midpoint on that curve corresponds to the dose that yields half the maximal effect.
- By definition, ED50 is that midpoint dose. Thus ED50 quantifies the mid-point of the dose–response relationship.

3. Calculations / intermediate demonstration
- If maximal response = 100 units, ED50 is the dose at which measured response = 50 units.
- On a typical sigmoidal dose–response plot, locate the response = 50% of maximum; the corresponding x-value (dose) is ED50.

4. Why the correct answer is correct
- ED50 is a direct descriptor of potency on the dose–response curve: lower ED50 = higher potency. It quantifies the central point (50% effect) of that curve, so “dose–response curve” is the correct referent.

5. Why other options are incorrect
- Molecular weight: a physicochemical property of a molecule, unrelated to ED50.
- Blood–brain transportation: refers to BBB permeability; ED50 does not measure transport across the BBB.
- Receptor density: influences response and potency but is not what ED50 quantifies; ED50 is an outcome on the dose–response curve, not a receptor count.

6. Conclusion
The correct answer is Dose-response curve, which matches the provided answer.

Question26 The ED50 ascribed to a drug quantifies the mid-point of the: Molecular weight Dose-response curve Blood-brain transportation Receptor density ResetMaximum marks: 1 Flag question undefined单项选择题

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