Which of the following are TRUE with regard to Sickle Cell Anemia and/or Sickle Cell Trait in modern human populations living near the equator?  (multiple answers possible) 多项选择题

Everyone who has the sickle cell gene, either in the full disorder or as a carrier, dies before reaching reproductive age, thus there is no adaptive advantage.

There is no adaptive advantage in these areas to having Sickle Cell Anemia or normal hemoglobin.

There is an adaptive advantage to having Sickle Cell Trait in areas where young people regularly die from malaria.

The prevalence of Sickle Cell Trait in equatorial areas is one piece of evidence that natural selection is currently at work in modern human populations.

Sickle Cell Trait provides natural resistance to malaria but is not good evidence of natural selection at work in humans.

Those with normal hemoglobin are more resistant to the malarial parasite, whereas those with Sickle Cell Anemia and Sickle Cell trait have little to no resistance.