Question text Captopril inhibits angiotensin II-converting enzyme (ACE). Which of the following changes in Vmax and Km of ACE are MOST LIKELY to occur in the presence of captopril? Multiple choice 1 Question 9increase in Vmax, decrease in Kmdecrease in Vmax, no change to Kmno change to Vmax, increase in Kmdecrease in Vmax, decrease in Km Captopril binds to ACE via: Multiple choice 2 Question 9phosphorylation of the serine-OH group at the allosteric site.covalent modification of the zinc-containing catalytic site.mimicking the structure of angiotensin I.its anionic site. Captopril treatment could be associated with: Multiple choice 3 Question 9increased levels of angiotensin I.direct antagonism of the AT1 receptor.increases in blood pressure.increased levels of angiotensin II.多项填空题
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Question text SECTION A: ENZYMATIC REACTIONS This section contains a total of 7 marks. You should allow 7-10 mins to answer the questions in this section. Jeroen is an honours student working in the La Trobe Institute for Molecular Sciences. He is testing the efficacy of a new compound "X" that he hopes inhibits the activity of the enzyme he is interested in, Lockdownase. He conducts a Michaelis-Menten assay where his enzyme, Lockdownase, is incubated in the presence of increasing concentrations of substrate, with a constant concentration of inhibitor X. He obtains the following Lineweaver-Burk plot: Using the data above, answer the following questions (1 mark each): Q1. A. Calculate the Km for the enzyme alone (give your answer to 3 decimal places). Answer 1 Question 1[input] Q2. Calculate the Kmfor the enzyme + inhibitor (give your answer to 3 decimal places). Answer 2 Question 1[input] Q3. Calculate the Vmax for the enzyme alone (give your answer to 3 decimal places).Answer 3 Question 1[input] Q4. Calculate the Vmax for the enzyme + inhibitor (give your answer to 3 decimal places).Answer 4 Question 1[input] Q5. What is the type of inhibitor used in this experiment? Answer 5 Question 1[select: , Competitive, Irreversible, Uncompetitive, Covalent] Q6. What would you alter in the reaction mixture to increase the activity of enzyme back to normal levels (i.e. to before compound X was added) even in the presence of the inhibitor? Answer 6 Question 1[input] Q7. Which of the following conditions are important to keep constant when measuring enzyme activity? Select all that apply.pHvolumetemperatureoxygen levels Ensure that you have entered and checked all your answers before pressing "Next page" as you will not be able to return to this page and these questions.
Which of the following statements about V0, Vmax, [S] and Km values is not true?
The Vmax of an enzyme is:
Is the following statement true or false?'There is an inverse relationship between the Km and an enzyme’s affinity for its substrate'.
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