A new drug candidate has been developed and the rate constant for its base-catalysed hydrolysis has been was found to vary with temperature. The rate constant at 25 °C was determined to be 1.053 × 10-3 h-1. Which formulation and storage recommendations, of the ones listed below, are appropriate?多项选择题
A
a. formulate at low pH
B
b. formulate at high pH
C
c. keep at room temperature up to 4 days
D
d. keep in a fridge for longer than 4 days
E
e. store in a dark glass bottle
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