In calculating a Reference dose (RfD) for a chemical, uncertainty factors are considered. Which of the following statements are true?多项选择题

A

An example of an uncertainty factor would be that we only have animal data and lack human data.

B

That the target tissue of the chemical is not fully understood would also be considered an uncertainty factor.

C

Another uncertainty factor would be if we do not know the solubility of the chemical.

D

To account for individual susceptibility/sensitivity, divide the NOAEL by 10.

E

To account for individual susceptibility/sensitivity, divide the NOAEL by 10.

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