Transit time for RBC through the spleen is about ten times longer than it is for other organs.  Which of the following are part of the explanation? (Select all the responses which are true - even if only one.)多项选择题

A

Terminal capillaries are open ended

B

RBC need to move through the interstitium of the spleen to enter the venous system

C

The marginal zone is made up of B-cells involved in immunological surveillance

D

Fenestrated venules act as a barrier for the movement of RBC

E

Passage through the splenic cords acts as a bottleneck for RBC movement

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