Question textYour research and development team are studying several compounds that interact with receptors of the autonomic nervous system. You have carried out a series of competition radioligand binding assays. The results are shown below. If your team was looking for a compound that targets muscarinic receptors in particular, which one of these compounds would be your BEST choice to investigate further? Multiple choice 1 Question 5LOL11LOL22LOL33LOL44 The above IC50 values for each compound provide a measure of its __________________ at each receptor tested. Multiple choice 2 Question 5concentration required to cause 50% of the compound’s maximum effectaffinityconcentration required to inhibit 50% of an agonist’s maximum effectantagonist potency多项填空题

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Question textYou are testing the hypothesis that MDD404 will act as a muscarinic receptor agonist. These results alone, prove your hypothesis that MDD404 acts as a muscarinic receptor agonist. Multiple choice 1 Question 3TrueFalse Which one of the following experimental outcomes would provide the BEST evidence that MDD404 is acting selectively? The response to MDD404 is: Multiple choice 2 Question 3similar to the response caused by a known selective muscarinic receptor agonist.inhibited by a muscarinic receptor antagonist.inhibited by muscarinic receptor antagonist, but not by an antagonist for another receptor.inhibited by an antagonist for another receptor, but is unaffected by a muscarinic receptor antagonist..

Question textYou are testing the hypothesis that your unknown is an agonist at the muscarinic receptor. The results of your experiment are shown below. What is the MOST LIKELY purpose of histamine in this experiment? To demonstrate whether: Multiple choice 1 Question 1the tissue’s reactivity has changed during the equilibration period with atropine.atropine is effective at the chosen concentration.the unknown agonist is acting selectively.atropine is acting selectively at the chosen concentration. Based on the results shown above, which one of the following conclusions can you MOST CONFIDENTLY make? Multiple choice 2 Question 1The unknown agonist might be acting non-selectively.Atropine is acting selectively at the chosen concentration.Histamine might be acting non-selectively.The unknown agonist is inducing this response via the muscarinic receptor alone.

Question textThe questions below relate to the following information about a series of experiments carried out to investigate the mechanism(s) of action of compounds, EAD01 - EAD04. A competition radioligand binding study was undertaken to test the binding of the compounds (EAD01 - EAD04) at β1 and β2 adrenoceptors. From these studies, the IC50 for each compound was determined at each of the receptor subtypes. The data obtained are provided in the following table. This radioligand binding study provides information about the relative ______________ of each compound at β1 and β2 adrenoceptors. Multiple choice 1 Question 16efficacysize of adverse effectsantagonist potencyaffinity Based on this data, the compound that shows the MOST selectivity for β2 adrenoceptors is: Multiple choice 2 Question 16EAD01EAD02EAD03EAD04 A second set of experiments with these compounds was conducted, using an isolated tissue preparation, expressing β1 receptors. The following table summarises the data obtained from these experiments. Based on the values derived from this set of experiments, it can be concluded that: Multiple choice 3 Question 16EAD01 has the lowest potency and the lowest efficacyEAD01 has the highest potency and highest efficacyEAD02 has the highest potency and the highest efficacyEAD02 has the lowest potency and the lowest efficacy Based on ALL of the above data provided for EAD04, it MOST LIKELY acts at the β1 adrenoceptor as a/n: Multiple choice 4 Question 16full agonistpartial agonistallosteric modulatorantagonist Please answer all parts of the question.

Question textThe questions below relate to the following information about a series of experiments carried out to investigate the mechanism(s) of action of compounds, EAD01 - EAD04. A competition radioligand binding study was undertaken to test the binding of the compounds (EAD01 - EAD04) at β1 and β2 adrenoceptors. From these studies, the IC50 for each compound was determined at each of the receptor subtypes. The data obtained are provided in the following table. This radioligand binding study provides information about the relative ______________ of each compound at β1 and β2 adrenoceptors. Multiple choice 1 Question 16efficacysize of adverse effectsantagonist potencyaffinity Based on this data, the compound that shows the MOST selectivity for β2 adrenoceptors is: Multiple choice 2 Question 16EAD01EAD02EAD03EAD04 A second set of experiments with these compounds was conducted, using an isolated tissue preparation, expressing β1 receptors. The following table summarises the data obtained from these experiments. Based on the values derived from this set of experiments, it can be concluded that: Multiple choice 3 Question 16EAD01 has the lowest potency and the lowest efficacyEAD01 has the highest potency and highest efficacyEAD02 has the highest potency and the highest efficacyEAD02 has the lowest potency and the lowest efficacy Based on ALL of the above data provided for EAD04, it MOST LIKELY acts at the β1 adrenoceptor as a/n: Multiple choice 4 Question 16full agonistpartial agonistallosteric modulatorantagonist

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