Question at position 17 The genotype of individual II-2 is Homozygous dominantHomozygous recessiveheterozygoushemizygousCannot be determined from the pedigree

Question

BlackTom AI · Accepted Answer

The question asks about the genotype of individual II-2 based on the given pedigree. 
Option 1: Homozygous dominant. This cannot be concluded with confidence because an unaffected daughter (II-2 is not shaded) could be AA or Aa depending on the inheritance pattern and the parents' genotypes. There is not enough information to confirm a dominant allele presence.
Option 2: Homozygous recessive. Similarly, II-2 being unaffected does not guarantee the two recessive alleles, since she could be Aa (carrier) or AA if the trait is autosomal; the pedigree does not provide sufficient parental allele details to confirm aa.
Option 3: Heterozygous. Without knowing whether the trait requires a single dominant allele or recessive alleles for expression, and without clear parental genotype information, II-2 could be Aa in some scenarios, but we cannot deduce this uniquely from the pedigree alone.
Option 4: Hemizygous. This term applies to sex chromosomes (e.g., males with XY). II-2 is a female (circle), so hematogeny (hemizygosity) is not applicable here for this individual based on the notation in the pedigree; thus this option is not supported by the data.
Option 5: Cannot be determined from the pedigree. Given the information shown, the inheritance pattern is not specified (autosomal dominant, autosomal recessive, or X-linked), and II-2’s own phenotype and parental genotypes do not fix her genotype uniquely. Therefore this is the most accurate conclusion.
In summary, because the pedigree lacks a clearly defined mode of inheritance and does not provide enough genotype information for II-2’s parents, we cannot determine II-2’s genotype with certainty from the pedigree alone.

Question at position 17 The genotype of individual II-2 is Homozygous dominantHomozygous recessiveheterozygoushemizygousCannot be determined from the pedigree单项选择题

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