Beginning at the glomerulus, place the following structures in the order that fluid would travel through a nephron.

Ascending limb of loop of Henle
Bowman’s (glomerular) capsule
Collecting duct
Descending limb of loop of Henle
Distal convoluted tubule
Glomerulus
Proximal convoluted tubule

Question

Beginning at the glomerulus, place the following structures in the order that fluid would travel through a nephron.

Ascending limb of loop of Henle
Bowman’s (glomerular) capsule
Collecting duct
Descending limb of loop of Henle
Distal convoluted tubule
Glomerulus
Proximal convoluted tubule

BlackTom AI · Accepted Answer

Filtrate leaves the glomerular capillaries into Bowman's capsule and then travels through the tubular segments of the nephron in a fixed anatomic sequence: Bowman's capsule → proximal convoluted tubule → loop of Henle (descending limb then ascending limb) → distal convoluted tubule → collecting duct.

1) Relevant knowledge points and concepts
- Filtration occurs at the glomerulus into Bowman's (glomerular) capsule.
- The proximal convoluted tubule (PCT) is the next segment and performs bulk reabsorption.
- The loop of Henle has a descending limb (permeable to water) followed by an ascending limb (impermeable to water, reabsorbs salts).
- The distal convoluted tubule (DCT) follows the loop and fine-tunes ion exchange under hormonal control.
- The collecting duct receives processed filtrate from DCTs and concentrates urine.

2) Step-by-step reasoning process
- Start at Glomerulus (number 6 in the list). Filtrate enters Bowman’s capsule next (number 2).
- From Bowman’s capsule the filtrate enters the proximal convoluted tubule (number 7).
- It then flows into the loop of Henle: first the descending limb (number 4), then the ascending limb (number 1).
- After the ascending limb it enters the distal convoluted tubule (number 5).
- Finally it drains into the collecting duct (number 3) for final concentration.

3) Intermediate mapping of numbers to names (from the question)
1 = Ascending limb of loop of Henle
2 = Bowman’s (glomerular) capsule
3 = Collecting duct
4 = Descending limb of loop of Henle
5 = Distal convoluted tubule
6 = Glomerulus
7 = Proximal convoluted tubule

Using that mapping gives the numeric sequence: 6 → 2 → 7 → 4 → 1 → 5 → 3.

4) Why the correct answer is correct
This sequence follows the anatomical and physiological order of filtration and tubular processing: glomerulus → Bowman’s capsule → PCT → descending loop → ascending loop → DCT → collecting duct, matching 6,2,7,4,1,5,3.

5) Why the other options are incorrect (briefly)
- Option 1 (6,1,7,5,3,2,4): Places the ascending limb immediately after the glomerulus and puts Bowman’s capsule late — anatomically impossible.
- Option 2 (6,5,4,1,7,3,2): Begins with distal convoluted tubule after glomerulus; DCT is downstream, so order is wrong.
- Option 4 (6,1,3,2,4,7,5): Has ascending limb and collecting duct before Bowman’s capsule and PCT — incorrect sequence.
- Option 5 (6,5,1,4,7,2,3): Starts with DCT after glomerulus and places Bowman’s capsule near the end — wrong.

6) Conclusion
The anatomically and physiologically correct path is 6, 2, 7, 4, 1, 5, 3, which matches the provided answer.

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