Which of the following statements about single nucleotide polymorphisms (SNPs) is CORRECT?

Question

BlackTom AI · Accepted Answer

When evaluating the statements about single nucleotide polymorphisms (SNPs), I’ll examine each option for accuracy and any common misconceptions.
Option 1: 'SNPs within a coding sequence will always result in a change in the amino acid sequence of the protein that is produced.' This is incorrect because SNPs in coding regions can be synonymous (silent) where the codon change does not alter the amino acid, or non-synonymous where it does change the amino acid. Therefore, not all coding SNPs alter the protein sequence.
Option 2: 'A large deletion that causes several hundred base pairs to be missing is a type of SNP.' This is mistaken because SNP stands for single nucleotide polymorphism, which involves a single base change. Large deletions are structural variants, not SNPs, and involve much more than a single nucleotide.
Option 3: 'SNPs are highly abundant in genomes.' This statement is true. SNPs occur frequently throughout genomes and are the most common type of genetic variation among individuals, making them useful as markers in various applications.
Option 4: 'SNPs are used for marker assisted selection because they are only present in intra-genic regions.' This is incorrect. SNPs are distributed throughout the genome, including intergenic regions, introns, and exons. They are valuable as markers partly because they are abundant, not because they are restricted to intragenic regions; the claim that they are only present in intra-genic regions is false and misleading.
In summary, the only statement that accurately describes SNPs among the given options is that SNPs are highly abundant in genomes. The other options contain factual inaccuracies or misleading simplifications that do not reflect the nature of SNPs as a genetic variation type.

Which of the following statements about single nucleotide polymorphisms (SNPs) is CORRECT?单项选择题

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