As a substrate for evolution to work upon, cis-regulatory sequences are excellent targets because?  多项选择题

A

Simple to modify or delete an enhancer compared to making subtle changes to the amino acid coding potential of a gene.

B

More likely to avoid lethality due to the continuation of other essential aspects of the gene's expression pattern.

C

Changes to switches of key developmental regulatory genes have the potential to create new circuits of gene regulatory activity., (Correct answer)Changes to switches of key developmental regulatory genes have the potential to create new circuits of gene regulatory activity.

D

A change may only impact a specific aspect of the overall expression of the gene.

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