An economic evaluation alongside a clinical trial can produce misleading cost-effectiveness estimate of the intervention if:多项选择题

A
a. There is only one relevant trial
B
b. The trial does not include the appropriate comparator
C
c. Health related quality of life was the primary outcome in the trial
D
d. Trial population differs from the typical population to receive intervention (e.g. younger and/or healthier)
E
e. The trial was executed in a different country
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