Active tDCS over which brain region seemed help reduce severity of auditory verbal hallucinations?

Question

BlackTom AI · Accepted Answer

1. Relevant knowledge points and concepts
Auditory verbal hallucinations (AVH) are commonly associated with abnormal activity in language-perception regions, particularly the left temporo-parietal junction (TPJ) and adjacent superior temporal gyrus (areas involved in speech perception and self–other attribution). Transcranial direct current stimulation (tDCS) modulates cortical excitability: anodal stimulation tends to increase excitability, while cathodal stimulation tends to decrease it. Reducing hyperactivity in the left TPJ can therefore diminish the neural mismatch that contributes to AVH.

2. Step-by-step reasoning
- Identify the brain region most strongly implicated in AVH: left TPJ/superior temporal language areas are repeatedly implicated in studies of hearing voices.
- Determine how tDCS is used: protocols that place the cathode (inhibitory) over the left TPJ aim to reduce pathological hyperactivity there, often paired with anodal placement over frontal areas to support top-down control.
- Link mechanism to clinical effect: lowering overactivity in left TPJ reduces aberrant speech-perception signals and misattribution of internal thoughts as external voices, producing reduced severity of AVH.

3. Calculations/intermediate steps
No numerical calculations apply. The logical intermediate steps are: AVH ← hyperactivity in left TPJ → cathodal tDCS reduces excitability → reduced AVH severity.

4. Why the correct answer is correct
Because clinical and neurophysiological evidence supports targeting the left temporo-parietal junction with inhibitory (or otherwise modulatory) tDCS to normalize overactivity in speech-perception circuits, active tDCS over the left TPJ has been shown to reduce the severity of auditory verbal hallucinations.

5. Why the other options are incorrect
- a. Right TPJ: less consistently implicated in AVH; the dominant language/hearing areas for AVH are left-lateralized.
- b. Right dorsolateral prefrontal cortex: DLPFC targets relate more to executive control and mood, not the primary perceptual source of AVH.
- c. Left dorsolateral prefrontal cortex: sometimes used to enhance cognitive control, but direct reduction of AVH severity is more consistently achieved by targeting left TPJ.

6. Conclusion
Therefore, active tDCS over the left temporal-parietal junction (option d) is the correct choice, matching the provided answer.

Active tDCS over which brain region seemed help reduce severity of auditory verbal hallucinations?单项选择题

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