Pseudomonas aeruginosa can modulate its production of outer membrane porins. A reduction in outer membrane porins can result in:[Fill in the blank]

Question

BlackTom AI · Accepted Answer

Question restatement: Pseudomonas aeruginosa can modulate its production of outer membrane porins. A reduction in outer membrane porins can result in: ______.

Option a: increased resistance to beta-lactams due to decreased uptake.
This is plausible because beta-lactam antibiotics often enter Gram-negative bacteria through outer membrane porins. If porin channels are reduced, the permeability for beta-lactams decreases, leading to lower intracellular concentrations and therefore higher resistance.

Option b: decreased resistance to beta-lactams due to increased uptake.
This would require more antibiotic to enter the cell, which contradicts the mechanism of porin reduction. A decrease in porins typically lowers, not raises, antibiotic uptake, so this option is inconsistent with known biology.

Option c: increased resistance to beta-lactams due to decreased efflux.
Porin loss affects entry into the cell (uptake), not the efflux pumps directly. While efflux can contribute to resistance, removing porins does not inherently increase resistance via decreased efflux; it would more directly impact uptake, making this rationale less direct and therefore less accurate for this specific scenario.

Option d: decreased resistance to beta-lactams due to increased efflux.
Again, porin reduction mainly reduces influx. An increase in efflux would also raise resistance, not decrease it. The combination of decreased porin with increased efflux could contribute to resistance, but the statement specifies decreased resistance, which contradicts the expected outcome of reduced entry.

In summary, the mechanism by which fewer outer membrane porins lower membrane permeability to antibiotics aligns with higher beta-lactam resistance due to reduced drug uptake. The remaining options misinterpret the relationship between porin expression, drug uptake, and resistance, or invert the direction of effect that porin loss would have on antibiotic entry.

Pseudomonas aeruginosa can modulate its production of outer membrane porins. A reduction in outer membrane porins can result in:[Fill in the blank]单项选择题

类似问题

Question at position 27 Which of the following will increase the development of antibiotic resistance?Improperly taking a vitaminNot finishing your antibiotic prescriptionTaking an antibiotic for an extended period of timeBoth answers 2 and 3Clear my selection

Question at position 18 European countries elimination in animal agricultural of growth promoting antibiotics (and those important to human health) resulted in a decreased incidence of antibiotic resistant infections in humans.FalseTrueClear my selection

Question at position 16 How many effective antibiotic treatments remain to treat antibiotic resistant gonorrhea?4130Clear my selection

更多留学生实用工具

智能学习助手

风格化写作助手

论文查重助手

文献引用助手

课堂转译助手

课堂笔记助手

Quiz搜索助手

学校历年真题

智能刷题助手

智能匹配练习

希望你的学习变得更简单