Question at position 59 What happens when a T cell recognizes a processed foreign antigen in association with a self-MHC molecule?It undergoes clonal expansionIt triggers B cell activation directlyIt immediately produces antibodiesIt is eliminated by apoptosis

Question

BlackTom AI · Accepted Answer

In this immunology scenario, when a T cell recognizes a processed foreign antigen presented by a self-MHC molecule, the typical outcome is clonal expansion of that specific T cell population.

Option 1: It undergoes clonal expansion. This is the correct pathway because T cells, upon recognizing an antigen-MHC complex, proliferate to increase the number of antigen-specific T cells capable of mounting an effective response. This expansion ensures an adequate army of T cells to perform help, cytotoxic functions, or other effector roles.

Option 2: It triggers B cell activation directly. While T helper cells can assist B cells to become antibody-secreting plasma cells, the direct triggering is not the B cell’s response. B cells require antigen presentation and T cell–dependent signals to undergo affinity maturation and class switching; the initial direct trigger here is T cell activation, not immediate B cell activation.

Option 3: It immediately produces antibodies. Antibody production is carried out by B cells, not by T cells. T cells do not secrete antibodies; instead, they coordinate the immune response, and B cells are the antibody factories.

Option 4: It is eliminated by apoptosis. Apoptosis of T cells is a mechanism used for negative selection (eliminating self-reactive T cells) or inactivation after an immune response, but the immediate consequence of recognizing a foreign antigen with self-MHC is activation and expansion, not wholesale deletion. apoptosis may occur later for regulation or tolerance in inappropriate contexts, but is not the standard first outcome of a typical antigen-MHC recognition event.

Overall, the key concept is that antigen recognition in the context of self-MHC drives clonal expansion of the specific T cells involved, enabling an effective cellular immune response, rather than directly activating B cells, producing antibodies, or causing immediate apoptosis.

Question at position 59 What happens when a T cell recognizes a processed foreign antigen in association with a self-MHC molecule?It undergoes clonal expansionIt triggers B cell activation directlyIt immediately produces antibodiesIt is eliminated by apoptosis单项选择题

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