Question at position 33 The activation of T cells by antigen-presenting cells is a key step in the adaptive immune response.TrueFalse单项选择题
A
True
B
False

Question

Question at position 33 The activation of T cells by antigen-presenting cells is a key step in the adaptive immune response.TrueFalse

BlackTom AI · Accepted Answer

Examining the statement about T cell activation and APCs requires unpacking what happens during the adaptive immune response.
Option 1 (True): This option correctly reflects core immunology. Antigen-presenting cells (APCs) such as dendritic cells, macrophages, and B cells process and present peptide fragments on MHC molecules to naive T cells. This interaction, often requiring a co-stimulatory signal, activates T cells and initiates clonal expansion and differentiation, central to adaptive immunity. For CD4+ T helper cells, antigens are shown on MHC class II, while CD8+ cytotoxic T cells recognize peptides on MHC class I. The APC-T cell engagement sets the stage for specific and tailored immune responses, including cytokine production, cytotoxic activity, and memory formation. The description aligns with established mechanisms of antigen presentation, T cell receptor recognition, and the need for co-stimulation to prevent anergy.
Option 2 (False): This statement would be incorrect because it denies a fundamental mechanism. If T cells were activated independently of APCs, or if APCs did not participate in presenting antigen to T cells, the adaptive immune response would lack specificity and proper activation signals, leading to ineffective immunity. In reality, APCs are essential for initiating T cell responses through MHC-mediated antigen presentation, along with co-stimulatory signals that drive full activation. Therefore, this option misstates a central concept of adaptive immunity.
In summary, option 1 accurately captures the critical role of APCs in activating T cells as a pivotal step in adaptive immunity, while option 2 contradicts well-established immunological principles by denying APC-mediated T cell activation.

Question at position 33 The activation of T cells by antigen-presenting cells is a key step in the adaptive immune response.TrueFalse单项选择题

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