Question at position 8 The SRY gene causes one to becomeandrogynousmalefemaleundifferentiatedsterile

Question

Question at position 8 The SRY gene causes one to becomeandrogynousmalefemaleundifferentiatedsterile

BlackTom AI · Accepted Answer

SRY is the testis-determining gene on the Y chromosome and its product is a transcription factor that initiates the male developmental program in the embryo.

Relevant knowledge points and concepts:
- SRY (Sex-determining Region Y) is located on the Y chromosome and is expressed in the bipotential gonad around 6–8 weeks of embryonic development.
- SRY upregulates SOX9 and other downstream genes, causing precursor cells to differentiate into Sertoli cells and form testes.
- Sertoli cells produce anti-Müllerian hormone (AMH) causing regression of Müllerian ducts; Leydig cells produce testosterone (and DHT) promoting development of Wolffian ducts and male external genitalia.

Step-by-step reasoning:
1. Embryos initially have bipotential gonads capable of becoming testes or ovaries.
2. Presence and expression of SRY triggers the cascade (SRY → SOX9 → Sertoli cell differentiation).
3. Sertoli cells secrete AMH, preventing female internal structures from developing.
4. Leydig cell-derived testosterone stabilizes and promotes male internal ducts (Wolffian) and, after conversion to DHT, masculinizes external genitalia.
5. Therefore, functional SRY causes the embryo to develop male gonads (testes) and male sexual characteristics.

Why "male" is correct:
SRY is specifically the switch that causes male (testicular) development. Its activity determines genetic male pathway, so the direct outcome of SRY expression is male sexual differentiation.

Why the other options are incorrect:
- Androgynous: SRY does not cause a mixed male/female phenotype; it drives a male pathway.
- Female/Undifferentiated: These are outcomes when SRY is absent or nonfunctional; they are the opposite of SRY action.
- Sterile: Sterility can occur in some conditions despite SRY (e.g., gonadal dysgenesis), but SRY’s primary role is sex determination, not directly causing sterility.

Conclusion: The correct answer is male, which matches the provided answer.

Question at position 8 The SRY gene causes one to becomeandrogynousmalefemaleundifferentiatedsterileSingle choice

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