Which enzyme is involved in generating small RNA duplexes from both miRNA and siRNA precursors?

Question

BlackTom AI · Accepted Answer

The question asks which enzyme generates small RNA duplexes from both miRNA and siRNA precursors.
Option 1: Drosha — This enzyme operates in the nucleus to cleave primary miRNA transcripts (pri-miRNAs) into precursor miRNAs (pre-miRNAs). It is involved in miRNA processing, not in generating the duplexes from both miRNA and siRNA precursors, so this choice is not correct for the stated role.
Option 2: Dicer — Dicer is the key RNase that processes double-stranded RNA precursors, including pre-miRNAs and long dsRNA or siRNA precursors, into short ~21–24 nucleotide duplexes. It functions in both miRNA and siRNA pathways to produce the small RNA duplexes that are later loaded into AGO-containing silencing complexes. This aligns with the described activity, making it the correct enzyme for generating small RNA duplexes from both precursor types.
Option 3: RNA-dependent RNA polymerase — This enzyme synthesizes RNA from an RNA template and is involved in RNA amplification in some organisms, but it does not primarily generate the characteristic small RNA duplexes from miRNA or siRNA precursors. Its role is distinct from Dicer’s processing activity.
Option 4: AGO — Argonaute proteins bind and utilize the mature small RNA for gene silencing within RISC, but they do not process precursors into duplexes. AGO acts downstream of Dicer in the silencing pathway, so it cannot be the enzyme generating the duplexes.

Which enzyme is involved in generating small RNA duplexes from both miRNA and siRNA precursors?单项选择题

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