Question at position 36 True or False. If the RISC complex with siRNA or miRNA holds the mRNA, then translation is inhibited.TrueFalse单项选择题
A
True
B
False

Question

Question at position 36 True or False. If the RISC complex with siRNA or miRNA holds the mRNA, then translation is inhibited.TrueFalse

BlackTom AI · Accepted Answer

Consider the statement about the RISC complex with siRNA or miRNA and its effect on mRNA.
Option 1: True. In RNA interference pathways, the RISC complex binds to complementary mRNA guided by the siRNA or miRNA. This binding typically results in either cleavage of the mRNA (especially with siRNA and perfect or near-perfect complementarity) or repression of translation (common with miRNA and partial complementarity). In either case, the outcome is reduced protein production from that mRNA, effectively inhibiting translation.
Option 2: False. If the claim were false, it would imply that binding by RISC does not affect translation, which contradicts the core mechanism of RNA interference. The binding of RISC to target mRNA is specifically to suppress gene expression, either by degrading the transcript or by blocking ribosome access and translation, so translation is not left uninhibited.
In summary, the central idea of RNAi—RISC guided by siRNA/miRNA leading to decreased translation or mRNA degradation—supports the statement as true, while denying this would ignore the established outcomes of RISC-mediated regulation.

Question at position 36 True or False. If the RISC complex with siRNA or miRNA holds the mRNA, then translation is inhibited.TrueFalse单项选择题

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