The discovery of RNA interference (RNAi) led to its use in biotechnology and medicine. All of the following are examples of how RNAi could be used in biotechnology or medicine, EXCEPT ________.

Question

BlackTom AI · Accepted Answer

RNA interference (RNAi) is a mechanism used to silence specific gene expression, and its applications span both therapeutic and research contexts. 
Option 1: 'to treat a disease characterized by the buildup of a specific protein.' This is plausible because RNAi can be designed to target and reduce the production of a protein that accumulates abnormally, thereby alleviating disease symptoms caused by protein buildup. 
Option 2: 'to treat a disease characterized by the normal expression of a dominant gene mutation.' In diseases caused by a dominant pathogenic allele, RNAi could be used to selectively knock down the mutant allele (ideally without affecting the normal allele), reducing the harmful effect of the mutation. Although specificity can be challenging, the concept is a recognized potential RNAi application. 
Option 3: 'to treat a disease characterized by the overexpression of a nonmutated gene.' If a gene is overexpressed and contributing to disease, RNAi can be employed to downregulate the expression of that gene, potentially restoring balance, so this fits RNAi utility. 
Option 4: 'to treat a disease characterized by a gene with a loss of function mutation.' Here, the underlying problem is reduced or absent gene function. RNAi further diminishes gene expression, which would exacerbate loss-of-function conditions rather than ameliorate them; this makes RNAi an inappropriate therapeutic strategy for such a disease. 
Option 5: 'to study loss-of-function phenotypes of specific genes in a model research organism.' RNAi is a standard tool for creating knockdown of genes to observe resulting phenotypes, a fundamental research application, so this is a valid use. 
In summary, most options describe ways RNAi could be used to modulate gene expression for therapeutic or research purposes, except the scenario where silencing a gene would worsen a loss-of-function condition, which makes that option the exception.

The discovery of RNA interference (RNAi) led to its use in biotechnology and medicine. All of the following are examples of how RNAi could be used in biotechnology or medicine, EXCEPT ________.单项选择题

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