What is a characteristic feature of the brain tissue in patients with Transmissible Spongiform Encephalopathies (TSEs)?

Question

BlackTom AI · Accepted Answer

The question asks for a characteristic feature of brain tissue in patients with Transmissible Spongiform Encephalopathies (TSEs).
Option 1: 'An abundance of healthy, functional neurons.' This is inconsistent with TSE pathology, where neurons are lost and replaced by vacuolated tissue, so this overstates neuronal preservation.
Option 2: 'Inflammation and immune response to foreign proteins.' TSEs typically show minimal inflammatory response in the brain; inflammation is not a defining hallmark, making this option misleading.
Option 3: 'Visible holes due to neuronal death.' This describes the classic spongiform change: vacuolation creating sponge-like holes in the neuropil and tissue due to neuron loss, which is a hallmark of TSE pathology.
Option 4: 'Overproduction of normal prion proteins.' In TSEs, the problem is misfolded prion proteins (PrPSc) aggregating, not an overproduction of normal PrP; this option mischaracterizes the mechanism.
Thus, option 3 correctly identifies the characteristic spongiform vacuolation pattern seen in TSE brain tissue, while the other options either misstate neuronal integrity, immune involvement, or prion biology.

What is a characteristic feature of the brain tissue in patients with Transmissible Spongiform Encephalopathies (TSEs)?单项选择题

类似问题

Question at position 67 Which of the following is NOT a human PRION disease?Chronic Traumatic EncephalopathyKuruFatal Familial InsomniaCreutzfeldt-Jakob DiseaseClear my selection

Question at position 60 Why is it so difficult to develop treatments for prion diseases?The causative agent is a self-proteinIt is not a bacteriaMutations make vaccine development difficultAll of the aboveClear my selection

Question at position 59 Which of the following is NOT a Transmissible Spongiform Encephalopathy (TSE)?KuruChronic Wasting DiseaseScrapieall are TSEsClear my selection

Question at position 49 The Kuru outbreak in Papua New Guinea was halted by:the imposition of a ban on a historical cultural practicethe eradication of a bat vectorproper sanitationthe development of a vaccineClear my selection

Question at position 31 Bovine spongiform encephalopathy is also known as:mad cow diseaseKurumad dog diseasecrazy cow diseaseClear my selection

A project has a required return of 12.6 percent, an initial cash outflow of $42,100, and cash inflows of $16,500 in Year 1, $11,700 in Year 2, and $10,400 in Year 4. What is the net present value?

更多留学生实用工具

智能学习助手

风格化写作助手

论文查重助手

文献引用助手

课堂转译助手

课堂笔记助手

Quiz搜索助手

学校历年真题

智能刷题助手

智能匹配练习

希望你的学习变得更简单