In an alternative placement described in Chapter 11.4, precipitation is introduced to replace polishing steps, but it has challenges. Which statement is NOT consistent with Chapter 11.4?单项选择题

A

Late precipitation can match or outperform conventional IEX for removal of some impurities in some cases

B

Late precipitation reduces the need to demonstrate precipitant clearance because polishing steps are replaced

C

A key challenge is proving downstream removal/clearance of residual precipitating agent

D

Late precipitation may be used to replace subsequent polishing chromatography operations

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