The conversion Folate to THF requires the addition of electron from NADH. Which of the below enzymes are inhibited by methotrexate to aid in treatment of acute leukemia?

Question

The conversion Folate to THF requires the addition of electron from NADH.  Which of the below enzymes are inhibited by methotrexate to aid in treatment of acute leukemia?

BlackTom AI · Accepted Answer

The question asks which enzyme is inhibited by methotrexate to aid in treatment of acute leukemia. 
Option 1: dihydrofolate oxidase. This enzyme is not the target of methotrexate; inhibitors of dihydrofolate oxidase are not used in standard methotrexate-based leukemia therapy, and this step is not the point of action for methotrexate.
Option 2: THF hydrolase. This enzyme is not a known clinical target for methotrexate in leukemia treatment, and inhibiting it would not specifically explain methotrexate’s therapeutic effect.
Option 3: dihydrofolate reductase. This is the classic and well-established target of methotrexate. Methotrexate competitively inhibits DHFR, preventing the reduction of dihydrofolate to tetrahydrofolate, thereby limiting the pool of THF required for one-carbon transfer reactions essential for purine and thymidylate synthesis in rapidly dividing leukemic cells.
Option 4: THF reductase. This label is not a standard enzyme name in this context; it resembles a misnomer for DHFR or a non-existent alternative. Since the action of methotrexate is not described by a distinct enzyme called THF reductase, this choice is inaccurate.
In summary, methotrexate’s therapeutic effect in acute leukemia stems from inhibition of dihydrofolate reductase, cutting off tetrahydrofolate production and disrupting nucleotide synthesis, while the other options either describe non-targets or misnamed enzymes.

The conversion Folate to THF requires the addition of electron from NADH. Which of the below enzymes are inhibited by methotrexate to aid in treatment of acute leukemia?单项选择题

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