When an antigen is bound to a Class I MHC molecule, it can stimulate a Blank 1 Question 19[select: , helper T cell, cytotoxic T cell, plasma cell]

Question

BlackTom AI · Accepted Answer

The question asks what type of cell is stimulated when an antigen is bound to a Class I MHC molecule.
Option A: helper T cell. This is incorrect for Class I MHC presentation because helper T cells (CD4+) primarily recognize antigens presented by MHC class II molecules, which are typically displayed by professional antigen-presenting cells. Therefore, they are not the main responders to peptides bound to MHC I.
Option B: cytotoxic T cell. This option is correct because cytotoxic T cells (CD8+) are the cells that recognize endogenous peptide antigens presented by MHC class I on nearly all nucleated cells. When recognized, they can become activated and proceed to kill the presenting cell or infected targets.
Option C: plasma cell. Plasma cells are differentiated B cells that produce antibodies. They do not recognize peptide-MHC I complexes to become activated; instead, B cells typically respond to antigen via B cell receptors and can require helper T cell signals for full activation and class switching, but plasma cells themselves are the antibody-secreting end product, not direct responders to MHC I peptide presentation.
Additional context: Class I MHC molecules present endogenous peptides (often from intracellular pathogens) and are involved in signaling cytotoxic responses, whereas Class II MHC molecules present exogenous peptides and engage helper T cell responses. This distinction explains why cytotoxic T cells are the appropriate responders in the Class I pathway.
In summary, recognizing a peptide bound to MHC I specifically engages cytotoxic T cells, not helper T cells or plasma cells, clarifying the immunologic role of each cell type in the context of MHC I presentation.

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