Question at position 66 Which is the correct order of the central dogma of molecular biology?Replication - Translation - TranscriptionTranscription - Replication - TranslationReplication - Transcription - TranslationTranscription - Translation - ReplicationTranslation - Transcription - Replication

Question

BlackTom AI · Accepted Answer

The question asks for the correct order of the central dogma of molecular biology, which is the flow of genetic information.
Option 1 proposes Replication - Translation - Transcription. This order incorrectly places translation before transcription, which would mean protein synthesis occurs before the RNA templates are produced. Since translation requires mRNA as a template, this sequence cannot reflect the actual biology.
Option 2 proposes Transcription - Replication - Translation. Here transcription occurs first, but replication is shown to come after transcription. In biology, DNA replication must precede transcription in many cellular contexts to ensure the genome double helix is duplicated before transcription of new RNA runs into multiple copies or potential genome instability; however, the standard canonical flow does not place replication after transcription, making this ordering incorrect.
Option 3 proposes Replication - Transcription - Translation. This sequence aligns with the well-established path: DNA is replicated to ensure genetic material is copied, then transcription uses the DNA (or the copy) to synthesize RNA, and finally translation uses RNA to synthesize proteins. This matches the textbook description of the central dogma and the directional flow from DNA to RNA to protein.
Option 4 proposes Transcription - Translation - Replication. In this arrangement, replication is last, which would imply genome duplication occurs after RNA and protein synthesis, contradicting the fundamental requirement that the genome be preserved and duplicated prior to gene expression activities.
Option 5 proposes Translation - Transcription - Replication. This sequence would imply proteins are made before any transcription or replication, which is biologically implausible since protein synthesis relies on RNA templates produced by transcription from DNA.
In summary, the reasoning above shows why the other orders fail to reflect the known sequential flow of information from DNA to RNA to protein, while the third option captures the canonical progression Replication → Transcription → Translation.

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