In its active state, the retinoblastoma protein (Rb) helps regulate the cell cycle by:单项选择题

A

a) Acting as a co-activator of S-phase genes

B

b) Phosphorylating p53 to promote DNA repair

C

c) Stimulating cyclin D/CDK4 activity

D

d) Binding and blocking E2F transcription factors

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类似问题

Which of the following options are the main functions of the G2/M cyclin/ CDK complex? To ensure that the components required for DNA synthesis are available To ensure the cell is ready to enter interphase To confirm that newly synthesised DNA fragments are not damaged To ensure the enzymes responsible for spindle fibre formation are produced

What is the Rb pathway responsible for?    

In order for a protein to fold correctly, there are several orders of structure that we discussed in lecture. For example, the secondary structure of a peptide requires [ Select ] in order to form correctly. If one had a Cdk protein, and there was a mutation or alteration in the primary sequence that affected the secondary structure, then that Cdk might not be able to interact with its partner called a [ Select ] cyclin regulin kinase mitosis-promoting factor . Or if that mutation was in the kinase domain of the protein, then the Cdk may not be able to carry out its enzymatic function, which involves the [ Select ] of substrate proteins. In the cell cycle, if a Cdk is unable to perform its job, that would likely trigger a [ Select ] , which would stop the cell cycle until things could be repaired. If one was able to sequence the DNA of the Cdk gene and find out what mutation it had, it is possible to correct that mutation by using [ Select ] to edit the DNA sequence and make it normal again. This technology has been applied in humans to a disease called sickle cell anemia, which is a good example of when one gene affects more than one phenotypic character, also known as [ Select ] .  

In order for a protein to fold correctly, there are several orders of structure that we discussed in lecture. For example, the secondary structure of a peptide requires [ Select ] disulfide bridges hydrogen bonds hydrophobic interactions Van der Waals interactions in order to form correctly. If one had a Cdk protein, and there was a mutation or alteration in the primary sequence that affected the secondary structure, then that Cdk might not be able to interact with its partner called a [ Select ] kinase cyclin mitosis-promoting factor regulin . Or if that mutation was in the kinase domain of the protein, then the Cdk may not be able to carry out its enzymatic function, which involves the [ Select ] hydrolysis phosphorylation inhibition cleavage of substrate proteins. In the cell cycle, if a Cdk is unable to perform its job, that would likely trigger a [ Select ] checkpoint non-disjunction polysomy reversal , which would stop the cell cycle until things could be repaired. If one was able to sequence the DNA of the Cdk gene and find out what mutation it had, it is possible to correct that mutation by using [ Select ] CRISPR CREDIT CHECKR CASPER to edit the DNA sequence and make it normal again. This technology has been applied in humans to a disease called sickle cell anemia, which is a good example of when one gene affects more than one phenotypic character, also known as [ Select ] pleiotropy aneuploidy epistasis heterozygosity .  

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