Acute hyperglycemia exceeding 10 mMol exceeds kidney reuptake capacity which leads to diuresis and ultimately hypovolemia. Glucose reuptake in the kidney relies on the sodium glucose co transporter 2 (SGTL2). This transporter relies on the maintenance of a sodium gradient by sodium/potassium ATP antiporter so is an example of secondary active transport. Its re-uptake capacity is limited by? Select all correct answers.多项选择题

题目图片
A

a. The total concentration of SGTL2 in the nephrons.

B

b. Vmax (the maximum velocity or rate at which a substrate can be moved),

C

c. Km​K, start subscript, m, end subscript (the affinity of SGLT2 for its substrate - in this case glucose)

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