Question text a. Sickle cell anemia is an autosomal recessive disorder. Sarah’s sister Kate has sickle cell anemia, but Sarah is unaffected, as are their parents. Sarah’s husband Bob also has sickle cell anemia (they met at an information session for sickle cell anemia sufferers and their families) and together they have had two children who do not have sickle cell anemia. Obligate carrier status is shown in generations I and III Using Bayesian analysis, fill in the first two rows of following table, providing each probability in decimals to a maximum of three decimal places if needed [table] | Sarah IS a carrier | Sarah IS NOT a carrier Prior Probability | Answer 1 Question 8 | Answer 2 Question 8 Conditional Probability | Answer 3 Question 8 | Answer 4 Question 8 Joint probability | | Posterior probability | | [/table] (4 marks) b. In a separate couple, David and Monica, David has tested negative for the autosomal recessive Wilson disease. The disease has a carrier frequency of 1/20 and the test has a false negative rate of 10%. Using Bayesian analysis, fill in the last two rows of the following table (the first two rows have already been completed), providing each probability in decimals to a maximum of four decimal places if needed [table] | David IS a carrier | David IS NOT a carrier Prior Probability | 0.05 | 0.95 Conditional Probability | 0.1 | 1 Joint probability | Answer 5 Question 8 | Answer 6 Question 8 Posterior probability | Answer 7 Question 8 | N/A [/table] (3 marks) c. Jessica attends genesRus and you have calculated that her posterior probability of being a carrier for an autosomal recessive condition is 0.048, while her husband Greg is a known carrier for this condition. What would be the probability that their first child is healthy (i.e. does not have the condition)? Provide your answer in decimals to a maximum of three decimal places if needed: Answer 8 Question 8[input] (2 marks)多项填空题