A 16‑year‑old undergoes an MRI scan as part of a research study. The radiology report notes a reduction in cortical thickness in the frontal lobes compared with scans taken at age 10. The teenager’s parents are alarmed, fearing that this indicates degenerative brain disease. Which explanation best fits this finding in a healthy adolescent?Single choice

A

A. It likely reflects abnormal neuron loss due to early onset neurodegenerative disease.

B

B. It is a normal consequence of extensive synaptic pruning during adolescence, especially in frontal regions.

C

C. It indicates that neurulation has failed to complete properly in the frontal cortex.

D

D. It shows that neurogenesis has permanently stopped in the frontal cortex, especially in orbitofrontal regions.

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