The process of relating the chemical structure to biological action is called Structure - Activity Relationship (SAR).判断题

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A

True

B

False

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N-arachidonyl-glycine (see structure below) was discovered as a glycine transport inhibitor that provided analgesia in chronic pain. However, the compound is not suitable for development as a drug because of low potency, metabolic instability and poor selectivity. To overcome these limitations, a series of bioactive lipids have been developed, including oleoyl-D-lysine (structure below). The following questions relate to the principles used to develop more potent, metabolically stable, and more selective compounds. Arachidonyl-glycine Oleoyl-D-lysine Oleoyl-D-lysine was developed from N-arachidonyl-glycine. What limitations does oleoyl-D-lysine overcome compared to N-arachidonyl-glycine? From the 4 statements, choose the best combination of responses to answer the question. The D-lysine amino acid limits metabolism compared to the glycine head group The oleoyl tail is less susceptible to oxygenation than the arachidonyl tail The more flexible oleoyl tail is better able to fit into the binding pocket. The positive charge on the lysine allows formation of π-cation bonds to improve potency

The process of relating the chemical structure to biological action is called Structure - Activity Relationship (SAR).

Project A has a required return on 9.2 percent and cash flows of −$87,000, $32,600, $35,900, and $43,400 for Years 0 to 3, respectively. Project B has a required return of 12.7 percent and cash flows of −$85,000, $14,700, $21,200, and $89,800 for Years 0 to 3, respectively. Which project(s) should you accept based on net present value if the projects are mutually exclusive?

You are considering two mutually exclusive projects. Project A has cash flows of −$72,000, $21,400, $22,900, and $56,300 for Years 0 to 3, respectively. Project B has cash flows of −$81,000, $20,100, $22,200, and $74,800 for Years 0 to 3, respectively. Both projects have a required 2.5-year payback period. Should you accept or reject these projects based on payback analysis?

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