Question at position 18 Although it is the rarest type, ______ is the most deadly type of skin cancer.melanomaKaposi sarcomabasal cell carcinomasquamous cell carcinomaClear my selectionSingle choice
A
melanoma
B
Kaposi sarcoma
C
basal cell carcinoma
D
squamous cell carcinoma

Question

Question at position 18 Although it is the rarest type, ______ is the most deadly type of skin cancer.melanomaKaposi sarcomabasal cell carcinomasquamous cell carcinomaClear my selection

BlackTom AI · Accepted Answer

Melanoma arises from melanocytes, the pigment-producing cells in the epidermis, and although less common than other skin cancers it has the highest potential to invade and metastasize, making it the most deadly type.

1) Relevant knowledge points and concepts
- Major types of skin cancer: basal cell carcinoma (BCC), squamous cell carcinoma (SCC), melanoma, and less commonly Kaposi sarcoma.
- Frequency vs. lethality: BCC is the most common but rarely metastasizes; SCC is common and has some metastatic risk; melanoma is rarer but far more likely to spread and cause death.
- Prognostic factors for melanoma: Breslow thickness (tumor depth), ulceration, and presence of metastases determine survival.
- Clinical recognition: ABCDE criteria (Asymmetry, Border irregularity, Color variation, Diameter >6 mm, Evolving lesion) help identify suspicious melanocytic lesions.

2) Step‑by‑step reasoning process
Step 1: Compare incidence and mortality. BCC and SCC comprise the majority of nonmelanoma skin cancers; melanoma is a minority of cases.  
Step 2: Compare metastatic potential. BCC very rarely metastasizes; SCC can metastasize but less frequently; melanoma has a high metastatic rate even when the primary lesion is small if invasive.  
Step 3: Relate to lethality. Because melanoma metastasizes to lymph nodes and distant organs (lungs, liver, brain), it causes disproportionately more deaths relative to its incidence.

3) Intermediate logical steps (explicit)
- Identify which type is rarest among choices: melanoma (rarer than BCC and SCC; Kaposi sarcoma is uncommon but geographically/clinically distinct).  
- Determine which of these has highest mortality: melanoma, due to early and aggressive metastasis and dependence of outcome on depth (Breslow).

4) Why the correct answer is correct
Melanoma originates in melanocytes and readily penetrates the dermis, enabling vascular and lymphatic spread; survival falls sharply with increased Breslow depth, so despite lower incidence it accounts for the majority of skin cancer deaths.

5) Why other options are incorrect
- Kaposi sarcoma: a vascular tumor associated with HHV‑8 and immunosuppression; not the classic most deadly cutaneous malignancy.  
- Basal cell carcinoma: most common skin cancer but very low metastatic potential and low mortality.  
- Squamous cell carcinoma: intermediate in risk; can metastasize but overall less lethal than melanoma.

6) Conclusion
Therefore, the most deadly (though rarest) type of skin cancer among the options is melanoma, which matches the provided answer: melanoma.

Question at position 18 Although it is the rarest type, ______ is the most deadly type of skin cancer.melanomaKaposi sarcomabasal cell carcinomasquamous cell carcinomaClear my selectionSingle choice

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