What would the conclusion be if you injected the stem cell niche of a developing chick spinal cord with a GFP-expressing retrovirus, collected and sectioned the spinal cord after birth, and found GFP+ labeled neurons, astrocytes, and oligodendrocytes?

Question

BlackTom AI · Accepted Answer

When GFP-expressing retrovirus is injected into the stem cell niche of a developing chick spinal cord and later GFP+ cells are found in multiple neural lineages (neurons, astrocytes, and oligodendrocytes), this indicates that the originally infected cell gave rise to all three major neural lineages observed. The retrovirus would have labeled the progenitor that was multipotent, capable of differentiating into multiple cell types within the CNS.

If the virus had labeled only one lineage (for example, only neurons), it would imply a lineage-restricted progenitor or a more lineage-restricted fate. If GFP were found in glial cells but not neurons, that would similarly argue for restricted potential rather than multipotency. The presence of GFP in neurons, astrocytes, and oligodendrocytes collectively demonstrates that the infected progenitor possessed multipotent properties at the time of labeling.

Therefore, the conclusion is that the retrovirus labeled a multipotent stem cell of the developing spinal cord, since a single infected progenitor produced multiple distinct neural lineages, demonstrating broad developmental potential within the CNS niche.

What would the conclusion be if you injected the stem cell niche of a developing chick spinal cord with a GFP-expressing retrovirus, collected and sectioned the spinal cord after birth, and found GFP+ labeled neurons, astrocytes, and oligodendrocytes?Single choice

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