All of the following are symptoms of hypothyroidism, EXCEPT:

Question

BlackTom AI · Accepted Answer

Thyroid hormones (T3 and T4) increase basal metabolic rate, heart rate, gastrointestinal motility, skin turnover and stimulate hepatic cholesterol metabolism. In hypothyroidism (reduced T3/T4) these processes are suppressed, producing the classic clinical features.

Step‑by‑step reasoning:
1. Metabolism and weight: Reduced thyroid hormone → lower basal metabolic rate → weight gain. This explains option g.
2. Cardiovascular effects: Thyroid hormone increases heart rate and contractility; deficiency → slow pulse (bradycardia) and reduced cardiac output → option f is consistent.
3. Thermoregulation and skin: Lower metabolic heat production and reduced sweating produce cold intolerance and decreased perspiration (options i and d). Reduced skin turnover and reduced eccrine/sebaceous activity cause coarse, dry skin (option b).
4. Neuromuscular and neuropsychiatric: Slowed mental and motor activity cause fatigue, apathy, lethargy and depression (options e and k).
5. Gastrointestinal: Decreased motility causes constipation (option h).
6. Growth and development: Thyroid hormones are essential for normal growth and neural development, so deficiency causes inhibited or impaired growth in children (option a).
7. Goitre: Low thyroid hormone causes elevated TSH; chronic stimulation (or autoimmune thyroiditis) often produces a goitre (option j).
8. Lipid metabolism: Thyroid hormone upregulates hepatic LDL receptors and cholesterol clearance. Hypothyroidism reduces LDL receptor activity and decreases cholesterol metabolism, causing hypercholesterolemia (elevated blood cholesterol), not low cholesterol.

Why option c is the correct EXCEPT answer:
- “Low blood cholesterol” is the opposite of what is expected in hypothyroidism. Rather than low cholesterol, hypothyroid patients typically have elevated LDL and total cholesterol. Therefore option c is not a symptom of hypothyroidism.

Briefly why other choices are incorrect as exceptions:
- Each other listed item (a, b, d, e, f, g, h, i, j, k) matches known physiological effects of low thyroid hormone and is a recognized symptom/sign.

Conclusion: The correct exception is c. Low blood cholesterol, which matches the provided answer.

All of the following are symptoms of hypothyroidism, EXCEPT:Single choice

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