How many hydrogen bonds could the non-steroidal anti-inflammatory drug (NSAID) naproxen theoretically participate in at the same time? A. 2
B. 4
C. 5
D. 7

Question

BlackTom AI · Accepted Answer

The carbonyl oxygen and the methoxy oxygen each can accept two hydrogen bonds, while the carboxylic OH provides one hydrogen-bond donor — giving a maximum of 5.

1) Relevant knowledge points:
- Hydrogen-bond donors are hydrogens attached to electronegative atoms (OH, NH). Naproxen has one OH in its carboxylic group → 1 donor.
- Hydrogen-bond acceptors are lone-pair-bearing electronegative atoms (O, N). An oxygen atom with two lone pairs can in principle accept up to two H‑bonds, subject to geometry.
- Naproxen’s key polar atoms: a carboxyl group (one C=O oxygen + one OH oxygen) and one methoxy oxygen (–OCH3).

2) Step-by-step reasoning:
- Identify donors: the carboxylic OH can donate one hydrogen bond → donors = 1.
- Identify acceptors and their maximum simultaneous capacity:
  - Carbonyl oxygen (C=O) has two lone pairs and can accept up to 2 hydrogen bonds simultaneously → acceptor capacity = 2.
  - Methoxy oxygen (–OCH3) has two lone pairs and can accept up to 2 hydrogen bonds → acceptor capacity = 2.
  - The OH oxygen is already being counted as the donor; while it has lone pairs, when it is simultaneously donating its hydrogen its capacity to accept additional H‑bonds is limited and typically not counted as an extra acceptor in the “simultaneous” maximum.
- Sum the simultaneous possible H‑bond interactions: carbonyl (2) + methoxy (2) + OH donor (1) = 5.

3) Intermediate “calculation” steps:
- donors = 1
- acceptors (C=O) = 2
- acceptors (OCH3) = 2
- total = 1 + 2 + 2 = 5

4) Why the correct answer is correct:
This count reflects the maximum number of hydrogen-bond interactions naproxen can theoretically engage at once, using the usual convention that each oxygen with two lone pairs can accept up to two H‑bonds and that the carboxylic OH supplies one donation while not also being treated as an additional acceptor in the simultaneous maximum.

5) Why the other options are incorrect:
- A (2): far too low – ignores multiple acceptor lone pairs on the two oxygens.
- B (4): corresponds to counting each oxygen as a single acceptor (carbonyl =1, methoxy =1) plus the OH donor = 3, or donors+acceptors counted differently; it undercounts the fact that C=O and ether O can each accept two H‑bonds.
- D (7): overestimates by double-counting lone pairs (or treating the OH both as a donor and as two acceptors) or otherwise exceeding realistic simultaneous geometry.

6) Conclusion:
Therefore the maximum number of hydrogen bonds naproxen could theoretically participate in at the same time is 5, matching answer C.

How many hydrogen bonds could the non-steroidal anti-inflammatory drug (NSAID) naproxen theoretically participate in at the same time? A. 2 B. 4 C. 5 D. 7Single choice

Similar Questions

How many hydrogen bonds could the non-steroidal anti-inflammatory drug (NSAID) naproxen theoretically participate in at the same time? A. 2 B. 4 C. 5 D. 7

Which of the following statement about Hydrogen bonds is correct?

When the molecules of ethanol, C2H5OH, are added to water, the ethanol molecules . 当乙醇分子 C 2 H 5 OH 加入水中时，乙醇分子会。

Which of the following statement about Hydrogen bonds is correct?

Which of the following statement about Hydrogen bonds is correct?

The unique properties of water are due to the _ of water molecules and the ability of water to form _ with other water molecules and with other polar molecules.

Each water molecule can hydrogen bond with ________ other water molecules

Which of the following statements is true for an ether?

More Practical Tools for Students Powered by AI Study Helper

Homework AI Solver

Stylized AI Paper Writer

Plagiarism Checker Assistant

Citation AI Academic Writing Tool

In-Class Translation Assistant

AI Note Generator

AI Quiz Answers

Past Exam Questions from University Test Bank

Smart Practice Assistant

Adaptive Practice

Making Your Study Simpler

How many hydrogen bonds could the non-steroidal anti-inflammatory drug (NSAID) naproxen theoretically participate in at the same time? A. 2 B. 4 C. 5 D. 7Single choice

Similar Questions

How many hydrogen bonds could the non-steroidal anti-inflammatory drug (NSAID) naproxen theoretically participate in at the same time? A. 2 B. 4 C. 5 D. 7

Which of the following statement about Hydrogen bonds is correct?

When the ________ molecules of ethanol, C2H5OH, are added to water, the ethanol molecules ________. 当乙醇________分子 C 2 H 5 OH 加入水中时，乙醇分子会________。

Which of the following statement about Hydrogen bonds is correct?

Which of the following statement about Hydrogen bonds is correct?

The unique properties of water are due to the ___ of water molecules and the ability of water to form ___ with other water molecules and with other polar molecules.

Each water molecule can hydrogen bond with ________ other water molecules

Which of the following statements is true for an ether?

More Practical Tools for Students Powered by AI Study Helper

Making Your Study Simpler

When the molecules of ethanol, C2H5OH, are added to water, the ethanol molecules . 当乙醇分子 C 2 H 5 OH 加入水中时，乙醇分子会。

The unique properties of water are due to the _ of water molecules and the ability of water to form _ with other water molecules and with other polar molecules.