If the two blue bases were deleted, predict what would happen to the protein sequence and determine if the protein would still be active. One sentence only.

Question

BlackTom AI · Accepted Answer

Deletion of two nucleotides causes a frameshift mutation, which alters the triplet reading frame and therefore changes every downstream codon, typically abolishing protein function.

1) Relevant knowledge points and concepts
- The genetic code is read in non-overlapping triplets (codons); insertion or deletion of a number of bases not divisible by three shifts the reading frame (frameshift).
- Frameshifts change amino acids downstream and often introduce a premature stop codon (UAA, UAG, UGA), producing truncated proteins.
- Loss or alteration of active sites or structural domains usually inactivates the protein.

2) Step-by-step reasoning
- Start with an example DNA coding sequence split into codons: ATG|AAA|GGA|CCC|TTT (translated as Met–Lys–Gly–Pro–Phe).
- Delete two bases inside the coding region; for example remove the second and third bases of the second codon (delete “AA” from the “AAA”).
- The sequence becomes ATG|A GGA|CCC|TTT when re-grouped into triplets from the original start. Re-grouped triplets are now ATG|AGG|ACC|CTT…
- The translated amino acids are now Met–Arg–Thr–Leu… entirely different from the original sequence, from the point of deletion onward.

3) Intermediate steps and calculation
- Original codons: [1] ATG [2] AAA [3] GGA [4] CCC [5] TTT
- After deleting two bases from codon 2, new grouping: [1] ATG [2] AGG [3] ACC [4] CTT …
- Every downstream amino acid identity changes; probability of encountering a stop codon in the shifted frame is high, so truncation is likely.

4) Why the correct answer is correct
- Because the two-base deletion shifts the reading frame, the resulting amino acid sequence is drastically altered (and frequently truncated), destroying the precise sequence/structure required for activity.

5) Why other options are incorrect
- The alternative (that the protein would remain active) is incorrect because proteins require correct amino acid sequences and intact domains; a frameshift almost always disrupts function.

6) Conclusion
- Therefore the correct outcome is: Not active. This matches the provided answer.

If the two blue bases were deleted, predict what would happen to the protein sequence and determine if the protein would still be active. One sentence only.Single choice

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