Active tDCS over which brain region seemed help reduce severity of auditory verbal hallucinations?

Question

BlackTom AI · Accepted Answer

1. Relevant knowledge points and concepts
Auditory verbal hallucinations (AVH) are commonly associated with abnormal activity in language-perception regions, particularly the left temporo-parietal junction (TPJ) and adjacent superior temporal gyrus (areas involved in speech perception and self–other attribution). Transcranial direct current stimulation (tDCS) modulates cortical excitability: anodal stimulation tends to increase excitability, while cathodal stimulation tends to decrease it. Reducing hyperactivity in the left TPJ can therefore diminish the neural mismatch that contributes to AVH.

2. Step-by-step reasoning
- Identify the brain region most strongly implicated in AVH: left TPJ/superior temporal language areas are repeatedly implicated in studies of hearing voices.
- Determine how tDCS is used: protocols that place the cathode (inhibitory) over the left TPJ aim to reduce pathological hyperactivity there, often paired with anodal placement over frontal areas to support top-down control.
- Link mechanism to clinical effect: lowering overactivity in left TPJ reduces aberrant speech-perception signals and misattribution of internal thoughts as external voices, producing reduced severity of AVH.

3. Calculations/intermediate steps
No numerical calculations apply. The logical intermediate steps are: AVH ← hyperactivity in left TPJ → cathodal tDCS reduces excitability → reduced AVH severity.

4. Why the correct answer is correct
Because clinical and neurophysiological evidence supports targeting the left temporo-parietal junction with inhibitory (or otherwise modulatory) tDCS to normalize overactivity in speech-perception circuits, active tDCS over the left TPJ has been shown to reduce the severity of auditory verbal hallucinations.

5. Why the other options are incorrect
- a. Right TPJ: less consistently implicated in AVH; the dominant language/hearing areas for AVH are left-lateralized.
- b. Right dorsolateral prefrontal cortex: DLPFC targets relate more to executive control and mood, not the primary perceptual source of AVH.
- c. Left dorsolateral prefrontal cortex: sometimes used to enhance cognitive control, but direct reduction of AVH severity is more consistently achieved by targeting left TPJ.

6. Conclusion
Therefore, active tDCS over the left temporal-parietal junction (option d) is the correct choice, matching the provided answer.

Active tDCS over which brain region seemed help reduce severity of auditory verbal hallucinations?单项选择题

类似问题

The implementation and loading phase of the Database Life Cycle (DBLC) involves _____.

Which of the following parameters is used to determine the concentration of protein in a spectrophotometer?

What are the units of absorbance?

What is the concentration of protein in the stock solution of BSA used for the standard curve?

When dissolved in water, hydrogen bromide (HBr) forms hydrobromic acid. Determine the hydroxide ion concentration in a 4,500 mL solution containing 3.78 g hydrogen bromide; K = 1.00 x 10¯14.

UVA radiation has a wavelength of approximately 390. nm. What is the energy of a photon of this light? (Planck's constant is 6.626 x 10 − 34 J s)

更多留学生实用工具

智能学习助手

风格化写作助手

论文查重助手

文献引用助手

课堂转译助手

课堂笔记助手

Quiz搜索助手

学校历年真题

智能刷题助手

智能匹配练习

希望你的学习变得更简单